medroxyprogesterone UK /mɛˌdɹɒk.sɪ.pɹəˈd͡ʒɛ.stə.ɹəʊn/US /məˌdɹɑk.sɪ.pɹoʊˈd͡ʒɛ.stəˌɹoʊn/ noun1 •A synthetic progesterone C₂₂H₃₂O₃ that is administered by injection as a long-acting contraceptive or is taken orally especially to treat amenorrhea and abnormal uterine bleeding and in conjunction with estrogen to relieve the symptoms of menopause and prevent osteoporosis.