progesterone UK /pɹəˈd͡ʒɛstəɹəʊn/US /pɹoʊˈd͡ʒɛstəˌɹoʊn/ noun2 •A steroid hormone, secreted by the ovaries, whose function is to prepare the uterus for the implantation of a fertilized ovum and to maintain pregnancy. •A synthetic version of the compound, used in contraceptive pills and other pharmaceutical products. formsprogesterones