Manhattanite adjective 1noun 1forms 1 adjective1 •Of, or from, Manhattan.This does not take into account the tens of thousands of New Yorkers who are harmlessly and charmingly insane in a peculiarly Manhattanite manner. — 1946 noun1 •Someone from Manhattan.Walter Gaskell was a tall, silver-haired Manhattanite with a narrow waist and broad shoulders, and his blue eyes had the luminous, emptied-out look of a reformed alcoholic's. — 1995 formsManhattanites