Mack truck noun3 •A motor vehicle produced by Mack Trucks, especially a semi-trailer.their hearts were too small to pump blood to their huge bodies. It was like trying to run a Mack truck on a Volkswagen engine, and their hearts gave out. — 2005 •A semi-trailer of any brand. •(figurative) Any unstoppable or enormous thing coming through.I sprung out of bed and was shoved back by a Mack truck of a headache. I powered through and felt my way to the door, focusing on a sliver of grayish light glowing through the curtains. — 2011 formsMack trucks