Louisiana /luːˌiːziˈænə/ noun4 •A state in the Deep South and South Central regions of the United States. Capital: Baton Rouge. Largest city: New Orleans.A federal judge has temporarily blocked a Louisiana law requiring the Ten Commandments to be displayed in every public school classroom by the new year. — 2024 •(historical) A vast territory in central North America. •(historical) An administrative district of New France. (1682–1769; 1801–1803) •(historical) A governorate of New Spain. (1769–1801)