locus UK /ˈləʊkəs/US /ˈloʊkəs/ noun4 •A place or locality, especially a centre of activity or the scene of a crime.The cafeteria was the locus of activity. •A fixed position on a string of DNA or RNA, especially a chromosome, that may be occupied by one or more genes. •The set of all points whose coordinates satisfy a given equation or condition.A circle is the locus of points from which the distance to the center is a given value, the radius. •[in the plural] A passage in writing, especially in a collection of ancient sacred writings arranged according to a theme. formsloci · locuses