knotful adjective 1noun 1forms 3 adjective1 •Full of knots; knotty.Is't more knotful or bewildered than the skein o'life itself, that a good tale tangles the better to unsnarl? — 2001 noun1 •A quantity that makes up a knot.The lice had eaten their way through her rotting flesh, leaving a skeleton double-row of teeth, and of a once proud neck, a knotful of tendons and veins. — 1977 formsknotfuls · more knotful · most knotful