keynote /ˈkiːˌnoʊt/noun 3verb 1forms 3 noun3 •The main theme of a speech, a written work, or a conference. •A speech that sets the main theme of a conference or other gathering; a keynote speech or keynote address.She delivered the keynote address at the conference.Innovation was the keynote of the company’s presentation. •The note on which a musical key is based; the tonic. verb1 •To deliver a speech that sets the main theme of a conference or other gathering. formskeynoted · keynoting · keynotes