jefe noun2 •(US) A boss in a business, company, or other organization.“They ain’t going to deliver the cattle across.... They’ve taken too much of a beating as it is. They’ve lost their big jefe and lots of men.” — 1982 •(US, informal) An officer with political influence; a head or chief in government, such as a sheriff, particularly where that person is Hispanic or of Mexican descent.Antonio Rivera Cabezas was chosen vice-jefe in March 1830. — 1887 formsjefes