isotope UK /ˈaɪ.sə.təʊp/US /ˈaɪ.sə.toʊp/noun 1verb 1forms 3 noun1 •Any of two or more forms of an element where the atoms have the same number of protons, but a different number of neutrons within their nuclei. Thus, isotopes have the same atomic number but a different mass number. verb1 •To define or demonstrate an isotopy of (one map with another). formsisotoped · isotoping · isotopes