irritability /ˌɪɹɪtəˈbɪlɪti/ noun3 •The state or quality of being irritable; quick excitability.Blue No. 1 and yellow No. 6 may also be toxic to some human cells. And as little as 1 milligram of yellow dye No. 5 may cause irritability, restlessness and sleep disturbances for sensitive children. — 2025 •A natural susceptibility, characteristic of all living organisms, tissues, and cells, to the influence of certain stimuli, response being manifested in a variety of ways.We find a renitency in ourselves to ascribe life and irritability to the cold and motionless fibres of plants. — 1800 •A condition of morbid excitability of an organ or part of the body; undue susceptibility to the influence of stimuli. formsirritabilities