Iowa /ˈaɪəwə/ noun2 •A state in the Midwestern region of the United States. Capital and largest city: Des Moines.I prefer to think of Iowa as I saw it through the eyes of a ten-year-old boy. Those were eyes filled with the wonders of Iowa’s streams and woods, of the mystery of growing crops. — 1951 •One of the Native Americans formerly occupying the region now included in the state of Iowa. formsIowas