inoculation UK /ɪˌnɒkjʊˈleɪʃən/US /ɪˌnɑkjəˈleɪʃən/ noun6 •The introduction of an antigenic substance or vaccine into the body to produce immunity to a specific disease. •The introduction of a microorganism into a culture medium. •Any technique to reduce harm by exposing oneself to a milder form of that harm.Practitioners might similarly employ stress inoculation strategies wherein clients visualize binegative situations—such as being subtly invalidated […] — 2019 •Synonym of prebunking. •An inoculum; that which is inoculated. •The insertion of the buds of one plant into another; grafting. formsinoculations