inoculate UK /ɪˈnɒkjuleɪt/US /ɪˈnɑːkjuleɪt/verb 5noun 1forms 3 verb5 •To introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease. •To safeguard or protect something as if by inoculation.Her upbringing overseas inoculated her against prejudice. •To add one substance to another.The culture medium was inoculated with selenium to investigate the rate of uptake. •(figurative) To introduce into the mind (used especially of harmful ideas or principles).You should not haue beleeu'd me, for vertue cannot so e[n]oculat our old stock, but vve shall relish of it, I loued you not. — 1599 •To graft by inserting buds. noun1 •Synonym of inoculum. formsinoculated · inoculating · inoculates