ibuprofen UK /ˌʌɪ.bjuː.ˈpɹəʊ.fən/US /ˌaɪ.bju.ˈpɹoʊ.fən/noun 1verb 1forms 3 noun1 •A synthetic compound used widely as an analgesic and anti-inflammatory drug. verb1 •(rare) To treat with ibuprofen; to administer ibuprofen to someone. formsibuprofened · ibuprofening · ibuprofens