hypostatic /haɪpəˈstætɪk/ adjective4 •Pertaining to hypostasis; depending upon, or due to, deposition or setting. •Pertaining to hypostasis, especially with reference to hypostatic union.The grand doctrine of the chymists, touching their three hypostatical principles. — 1661 •Personal, or distinctly personal; relating to the divine hypostases, or substances.The hypostatic union, as it is called, the perfect and complete union of two whole and perfect natures in the person of Jesus Christ, underlies this apparent paradox — 1659 •Of a gene, affected by hypostasis. formsmore hypostatic · most hypostatic