hypoactivate /ˌhaɪ.poʊˈæktɪveɪt/ verb1 •To reduce the level of activation or activity of (a process, region, or function), especially in biological or neural contexts.Among the various effects, they hyperactivate, hypoactivate, or inhibite limbic and other circuits, disorganize circuit activity, and interfere with effective functioning of the organism. — 1974 formshypoactivated · hypoactivating · hypoactivates