hydroxychloroquine UK /hʌɪˌdɹɒk.sɪˈklɔː.ɹə(ʊ).kwiːn/US /haɪˌdɹɑk.siˈklɔɹ.ə.kwɪn/ noun1 •A drug derived from quinolone that is taken orally in the form of its sulfate C₁₈H₂₆ClN₃O·H₂SO₄ to treat malaria, rheumatoid arthritis, and lupus erythematosus.