hybridoma noun1 •A hybrid cell engineered from a lymphocyte and a tumour cell; used to generate monoclonal antibodiesAthymic (nude) mice and rats were inoculated intraperitoneally with rat-mouse hybridoma cells secreting monoclonal antibodies to rat MHC class I antigens in order to improve the yield of antibodies. — 1982 formshybridomas · hybridomata