Houston, we have a problem UK /ˈh(j)uːst(ə)n ˌwiː hæv ə ˈpɹɒbləm/US /ˈ(h)justən ˌwi hæv ə ˈpɹɑbləm/ phrase1 •(humorous) Used to report that a (major) problem has occurred.Houston, we have a problem. We're running out of oil! The petroleum that fuels our daily lives is getting harder to find. — 2002