hoss /hɔːs/ noun3 •(Southern-US, slang) A big, strong and respected or dependable person, usually a man; one who is large like a horse.So here I was, fondling all sorts of fine mats, when a hoss of a woman screeched into her cell phone, rattling the lamps in the light fixture aisle. — 2004 •(Southern-US, slang) Term of address for a man.What's up, hoss? •(US, slang) A car. formshosses