hippocampus UK /ˌhɪpə(ʊ)ˈkæm.pəs/US /ˌhɪpəˈkæm.pəs/ noun2 •A part of the brain located inside the temporal lobe, consisting mainly of grey matter. It is a component of the limbic system and plays a role in memory and emotion.The hippocampus is central to the laying down of memories. — 2019 •A mythological creature with the front head and forelimbs of a horse and the rear of a fish. formshippocampi · hippocampuses