herpes UK /ˈhɜː(ɹ).piz/US /ˈhɚ.piz/ noun1 •A viral infection, caused by Human alphaherpesvirus 1 and Human alphaherpesvirus 2, marked by painful, watery blisters in the skin or in the mucous membranes or on the genitals.This, of course, is something only people with that STI would know. For example, herpes is 437737. — 2017 formsherpeses