hepaticopancreaticoduodenectomy /ˌhɛpətəkoʊˌpæŋkriˌætɪkoʊˌduːoʊˌdɛnˈɛktəmi/ noun1 •A major surgical procedure involving en bloc resection of the liver, pancreas, and duodenum, typically performed to treat advanced malignancies of the biliary tract or periampullary region. formshepaticopancreaticoduodenectomies