duodenum UK /ˌdjuːə(ʊ)ˈdiːnəm/US /ˌduəˈdinəm/ noun1 •The first part of the small intestine, starting at the lower end of the stomach and extending to the jejunum.The Intestina tenuia were burnt in many places, but not quite through any where, excepting two or three. […] The length of that which is commonly call'd the Duodenum, was about 4½ Foot. — 1682 formsduodena · duodenums