hamstring /ˈhæmstɹɪŋ/noun 2verb 2forms 4 noun2 •One of the great tendons situated in each side of the ham, or space back of the knee, and connected with the muscles of the back of the thigh.Lanctot slipped the tourniquet around the other, just under his groin, and twisted it tight, clamping quadriceps and hamstring hard to bone. — 2021 •The biceps femoris, semimembranosus, and semitendinosus muscles. verb2 •To lame or disable by cutting the tendons of the ham or knee; to hough. •(figurative) To cripple; to incapacitate; to disable.So have they hamstrung the valor of the subject by seeking to effeminate us all at home. — 1641 formshamstringed · hamstrung · hamstringing · hamstrings