Guadalajara /ˌɡwɑːdələˈhɑːɹə/ noun3 •A city, the capital of Jalisco, in central Mexico.For much of the 20th century, the image of Mexico popularized abroad through film, music, art and literature was, more accurately, a portrayal of Jalisco state and especially its capital, Guadalajara. — 2023 •A province of Castilla-La Mancha, Spain. Capital: Guadalajara. •A city, the capital of Guadalajara, Spain.