globulin UK /ˈɡlɒbjʊlɪn/US /ˈɡlɑbjəlɪn/ noun1 •Any of a group of simple proteins, soluble in water only in the presence of salts, that are coagulated by heatThe most effective approach to delaying and preventing recurrent HBV infection has been high dose immune globulin (anti-HBsIg) perioperatively and postoperatively (table 4). — 1993 formsglobulins