forkhead noun4 •A sequence of amino acids that forms a motif, in FOX proteins, that binds to DNA. •The forked end of a rod in a knuckle joint or similar. •(offensive, euphemistic) Euphemistic form of fuckhead. •(no longer used) An arrow with a barbed tip.With that at him a quiv'ring dart he threw, / With so fell force, and villeinous despite, / That through his haberjeon the forkehead flew, / And through the linked mayles empierced quite […] — 1590 formsforkheads