fisticuffs UK /ˈfɪs.tɪ.kʌfs/US /ˈfɪs.tɪˌkəfs/ noun[plural only]2 •(informal) An impromptu fight with the fists, usually between only two people.People who share a cell in the Basti[l]le […] if they do not immediately fall to fisticuffs, will find some possible ground of compromise. — 1881 •(old-fashioned) Bare-knuckled boxing, a form of boxing done without boxing gloves or similar padding.In his college days of athletic exercises, Mr. Crisparkle had known professors of the Noble Art of fisticuffs, […] — 1870