fist-fuck noun 1verb 1forms 3 noun1 •(slang, vulgar) Sexual practice in which a (fisted) hand is inserted and moved in or around the vagina or rectum. verb1 •(slang, vulgar) To insert and remove and move a (fisted) hand in someone's vagina or rectum.HIV could be transmitted if a person with a cut on their hand fistfucked their partner and caused bleeding in their rectum or vagina. — 1990 formsfist-fucked · fist-fucking · fist-fucks