fat-soluble adjective2 •Soluble in lipids, and in organic solvents; soluble in fats. •Tending to accumulate in the fat and adipose tissue of the body.Lyme Disease toxins and most of the toxins produced by industrialized manufacturing are fat-soluble, so named because they accumulate in the body's fat stores. — 2007 formsmore fat-soluble · most fat-soluble