ethionamide UK /ˌɛθ.iˈɒn.ə.mʌɪd/US /ˌɛθ.iˈɑn.əˌmaɪd/ noun1 •An antibiotic prodrug C₈H₁₀N₂S effective only against mycobacteria and used in the treatment of tuberculosis and leprosy. formsethionamides