esomeprazole /ˌɛs.oʊˈmɛp.ɹəˌzoʊl/ noun1 •An isomer of omeprazole (trademark Nexium) that is administered in the form of its magnesium salt (C₁₇H₁₈N₃O₃S)₂Mg especially in the treatment of erosive esophagitis, gastroesophageal reflux disease, and duodenal ulcer.