Equagesic /ɛkwəˈdʒiːzɪk/ noun1 •(historical) Trade name for a combination drug containing aspirin and meprobamate.If you are taking an anticoagulant (blood-thinning medication ) and have been given a new prescription for Equagesic, be sure that your doctor is aware that there is Aspirin in Equagesic. — 1990 formsEquagesics