endotome noun3 •A medical instrument consisting of scissors with curved blades and long crossing handles, originally used for decapitating a fetus.MATTEI'S ENDOTOME is a powerful instrument working on a scissors-joint; the shanks are double curved, so that by approximating the handles the curved blades can be brought together — 1867 •A retractable blade that allows great control over the depth of an incision, used for myotomy and arthrotomy.The endotome is introduced through the left upper quadrant port; the blade advanced out of its sheath in its entirety. — 1993 •The somite cells that eventually give rise to the endothelium. formsendotomes