dysphonia UK /dɪsˈfəʊ.ni.ə/US /dɪsˈfoʊ.ni.ə/ noun1 •A difficulty in producing vocal sounds.In patients with spasmodic dysphonia, the current treatment that is most commonly offered is by selective injection of botulinum toxin (BOTOX) into the most affected muscles. — 2009 formsdysphonias