disquietude

noun2

1. •
   A state of disquiet, uneasiness, or anxiety.

   • For with Rosilia, to the regret of the past and self-accusation, was added the contemplation of a dark futurity, seldom affording a gleam of hope to cheer and solace her disquietude. — 1838
2. •
   A fear or an instance of uneasiness.

   • The cares and disquietudes of the marriage-state, quoth Mrs. Wadman, are very great. — 1813