desquamatory adjective4 •Related to the shedding of endothelial cells.It is only when the sediment is very abudant, pointing to an exaggerated desquamatory condition, that our attention is called to the condition. — 1895 •Pertaining to the shedding or peeling off of the outermost layer of skin cells.For our purposes, it is sufficient to note that dysregulation of desquamatory protease activity in the SC is often involved in conditions of compromised skin barrier. — 2015 •Pertaining to exfoliation •Relating to the removal of the laminae of exfoliated bones.