despair UK /dɪˈspɛə(ɹ)/US /dɪˈspɛɚ/noun 3verb 3forms 5 noun3 •the deep sadness of someone who has given up all hopeHe turned around in despair, aware that he was not going to survive.My daughter's behavior drives me to despair. •That which causes despair. •That which is despaired of. verb3 •To cause to despair.Thinking of what I was despairing about despaired me further — 2019 •To be hopeless; to have no hope; to give up all hope or expectation.We despaired even of life. — 1611 •(no longer used) To give up as beyond hope or expectation; to despair of.I would not despair the greatest design that could be attempted. — 1644 formsdespaired · despairing · despaireth · despairs · despairest