desertification UK /dɪˌzɜː.tɪ.fɪˈkeɪ.ʃən/US /dɪˌzɝ.tɪ.fɪˈkeɪ.ʃən/ noun1 •The process by which a geographic region becomes a desert, resulting from natural changes in climate or by human activity.Desertification, as defined by the CCD, means "land degradation in arid, semi-arid and dry sub-humid areas resulting from various factors, including climatic variations and human activities." — 1998