depsipeptide noun1 •any of a class of polymeric compounds having both peptide and ester linkages, often alternating.For example, the antitumour depsipeptide kahalalide F was isolated from the opisthobranch mollusc Elysia rufescens, and is used by both the mollusc and its dietary alga Bryopsis spp. — 2016 formsdepsipeptides