depopulate UK /diːˈpɒpjəleɪt/US /diˈpɑpjəleɪt/verb 3adjective 2forms 3 verb3 •To reduce the population of a region by disease, war, forced relocation etc.Where is this viper / That would depopulate the city and / Be every man himself? — 1608 •To become depopulated, to lose its population.[…] the country […] has been rapidly depopulating, and utterly draining of its vital resources, till the unhappy population have sunk to the lowest depth of misery. — 1849 •To remove the components from a circuit board. adjective2 •(no longer used) Depopulated.And so in that realme were continually two kynges, vntil the kynge of Mede had depopulate the country, and brought the people in captiuite to the citie of Babylon: […] — 1531 •(no longer used) Barren, devoid of inhabitants; utterly destroyed, devastated.A world it was to see […] his daily peregrinacion in the desert, felles and craggy mountains of that bareine vnfertile and depopulate countrey. — 1548 formsdepopulated · depopulating · depopulates