depolarization UK /diːˌpəʊ.ləɹaɪˈzeɪ.ʃən/US /diˌpoʊlɚˌaɪˈzeɪʃən/ noun3 •The act of reducing polarity, or the result of such action; reduction to an unpolarized or less polarized condition. •An intracellular shift in electrical charge distribution, resulting in less negative charge inside the cell compared with outside; it is essential to the function of many cells, communication between cells, and the overall physiology of an organism. •Reduction of political polarization. formsdepolarizations