defatigable [dɪˈfætɪɡəbəɫ] adjective1 •(rare) Easily tired or wearied; capable of being fatigued.The author wishes to acknowledge the help of his peerful editor, Fredrica Friedman, and his defatigable researcher, Susan Hall, as well as that of his severest critic, P. Bear. — 2001 formsmore defatigable · most defatigable