crosstalk noun 5verb 1forms 3 noun5 •Conversation that is incidental to the topic under discussion.I couldn't hear the opening address because of all the crosstalk around me. •Undesirable signals from a neighbouring transmission circuit; undesired coupling between circuits. •The situation where one or more components of a signal transduction pathway affect another pathway. •Communication between parties who have extremely different perspectives.Sharing resources for mutual benefit: crosstalk between disciplines deepns the understanding of mycorrhizal symbioses. — 2020 •A traditional Chinese comedic performance in the form of a dialogue. verb1 •To hold an incidental conversation formscrosstalked · crosstalking · crosstalks