cost of doing business noun2 •The total ordinary expenses, such as materials, labor, and taxes, necessarily incurred in operating a commercial enterprise.Once you factor in rent, staff, and inventory, the cost of doing business around here eats up nearly half of gross revenue. •An unwelcome or regrettable but predictable and unavoidable risk, loss, or inconvenience accepted as an inherent part of pursuing a particular goal or aim, especially when the risk may be impractical or counterproductive to try to reduce or eliminate.Civilian casualties are just the cost of doing business when conducting a military operation in a dense urban enviroment.