confounding noun 2adjective 1forms 3 noun2 •The act by which things are confounded, or confused. •The process by which an apparent association between an exposure and an outcome is actually explained by another factor.Confounding is defined as the confusion or distortion of measures of association between exposure and outcome as a result of third (or more) variable(s). — 2013 adjective1 •Confusing, bewildering, baffling or perplexing.We have to with a Heart searching God, who will find out every unworthy Communicant to his utter Shame and Confusion ; when God examins such, his Questions will be Nonplussing and Confounding,[…] — 1716 formsconfoundings · more confounding · most confounding