comorbidity UK /ˌkəʊmɔːˈbɪdɪti/US /ˌkoʊmoɹˈbɪdɪti/ noun3 •The presence of one or more disorders (or diseases) in addition to a primary disease or disorder.Extensive comorbidity is the hallmark of immunodeficiencies. •A disease thus coexisting.Coronary artery disease is often a comorbidity of diabetes mellitus. •The effect of such additional disorders or diseases. formscomorbidities