commissure UK /ˈkɒm.ɪs.jʊə/US /ˈkɑm.əˌʃʊɹ/ noun3 •The joint between two bones....that round about the commissure of all our joints... — 1734 •A band of nerve tissue connecting the hemispheres of the brain, the two sides of the spinal cord, etc. •The line where the upper and lower lips or eyelids meet. formscommissures